Can I exclude a specific file or folder only by entering a file path name in the exclusions window?

No. You can only enter wildcards to exclude files or folders; entering a full path name will have no result. If you want to exclude only one folder or file from backup, the easiest way to do so is to open the Backup tab and deselect the file or folder.

See our full guide to setting exclusions for more assistance setting wildcard exclusions.